DES1 Inhibitor

Product Overview

• Article Name: DES1 Inhibitor
• Biozol Catalog Number: ECH-B-0027
• Supplier Catalog Number: B-0027
• Alternative Catalog Number: ECH-B-0027-10MG,ECH-B-0027-50MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

SKI-II is a commonly used inhibitor of both sphingosine kinase I (SPHK1) and 2 (SPHK2). Recently it has been shown to inhibit dihydroceramide desaturase (Des1) which Aurelio et al. suggest is actually responsible for its anti-proliferative activity, not SPHK inhibition. Compound 34 is an analog of SKI-II and is a selective Des1 inhibitor which shows no activity against either SPHK1 or SPHK2. 34 inhibits PC3 cell growth (GIC50 = 0.34 µM) but some of this may be due to inhibition of another target

References

L. Aurelio, C.V. Scullino, et al.. ''From Sphingosine Kinase to Dihydroceramide desaturase: A Structure?Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II) J. Med. Chem., 59, 965-984, DOI: 10.1021/acs.jmedchem.5b01439.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Inhibitor, Sphingolipid. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature