1R,2R-B13 (Ceramidase inhibitor)

Product Overview

• Article Name: 1R,2R-B13 (Ceramidase inhibitor)
• Biozol Catalog Number: ECH-B-0042
• Supplier Catalog Number: B-0042
• Alternative Catalog Number: ECH-B-0042-10MG,ECH-B-0042-25MG,ECH-B-0042-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Ceramides are bioactive sphingolipids which induce apoptosis in cells. Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy. B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes.

Storage

-20 C or below.

References

1) A. Bielawska, C.M. Linardic, Y. Hannun Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs J. Biol. Chem., 1992, 267, 18493-7. 2) M. Raisova, G. Goltz, et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes FEBS Letters 2002, 516, 47-52. 3) Bhabak, Krishna P., Kleuser, Burkhard Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues Bioorganic & Medicinal Chemistry 2013, 21, 874-882.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Inhibitor, Sphingolipid. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature