CYM50308 is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM - 79.1nM. It is inactive against the S1P1, S1P2, and S1P3 receptors up to 25 µM, and the S1P5 receptor up to 2.1 µM.
Storage
4 C
References
1) Urbano et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2- (alkylimino)thiazolidin-4-one chemotype, Bioorganic & Medicinal Chemistry Letters, 2011, 6739-6745. 2) Guerrero et al. Identification of a novel agonist of the sphingosine 1-phosphate receptor 4 (S1P4), Probe Reports from the NIH Molecular Libraries Program. http://www.ncbi.nlm.nih.gov/books/NBK143556/
