FPA-124 (Akt Inhibitor)

Product Overview

• Article Name: FPA-124 (Akt Inhibitor)
• Biozol Catalog Number: ECH-B-0101
• Supplier Catalog Number: B-0101
• Alternative Catalog Number: ECH-B-0101-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

FPA-124 is a cell-permeable inhibitor of Akt (IC50 = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC50 values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity.

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Solubility

DMSO: 5 mg/mL

Storage

Store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) V. Barve, et al. Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells J. Med. Chem., 2006, 49, 3800-3808. 2) Biscetti, F., G. Straface, et al. (2009). Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation. Cardiovasc Diabetol 8: 49. 3) Brito, P. M., R. l. Devillard, et al. (2009). Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis 205(1): 126.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Akt, Inhibitor. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature