SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is found in hematolymphoid cells and mesancymal stem cells. K118 is a water soluble SHIP1 inhibitor which does not inhibit SHIP2. Treatment with K118 (10 mg/kg) on obese mice on a high fat diet resulted in reduced body mass and lowered fat content when compared to pre-treatment and non-treated control animals. The treated mice had reduced blood glucose and insulin levels in addition to improved glucose tolerance. K118 treatment also reduced the amount of age-related fat accumulation in mice.
Storage
4 C or below
References
1) R, Brooks, et al. Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi, Stem Cells, 2015, 33, 848-858. doi:10.1002/stem.1902 2) N. Srivastava A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome JCI Insight, 2016, 1, e88544 doi:10.1172/jci.insight.88544.
