K149 (SHIP2 Inhibitor)

Product Overview

• Article Name: K149 (SHIP2 Inhibitor)
• Biozol Catalog Number: ECH-B-0345
• Supplier Catalog Number: B-0345
• Alternative Catalog Number: ECH-B-0345-10MG,ECH-B-0345-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. PI(3,4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. Treatment of colorectal cancer cells with K149 (2uM) decreases PKB/Akt signaling and sensitizes the cells to 5-fluorouracil regardless of whether the cell lines have a PI3KCA mutation.

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Storage

-20 C or below

References

1) E. Hoekstra, A.H. Das, et al. ''Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation Oncotarget 2016, 7:73525-73540. DOI: 10.18632/oncotarget.12321

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Inhibitor, SHIP. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature