SF1670 (PTEN Inhibitor)

Product Overview

• Article Name: SF1670 (PTEN Inhibitor)
• Biozol Catalog Number: ECH-B-0350
• Supplier Catalog Number: B-0350
• Alternative Catalog Number: ECH-B-0350-10MG,ECH-B-0350-1MG,ECH-B-0350-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

SF1670 is an inhibitor of PTEN (IC50 = 2 µM). PTEN (Phosphatase and Tensin Homolog deleted on Chromosome 10) is a 3 phosphoinositide phosphatase that converts PI(3,4,5)P3 to PI(4,5)P2 thus opposing PKB/Akt activation by PI 3-K. Pretreatment of neutrophils with SF1670 leads to enhanced fMLP-1 induced PI(3,4,5)P3 signaling effects such as Akt phosphorylation, NADPH oxidase-mediated superoxide formation, cell polarization, chemotactic migration, and phagocytosis. SF1670 also inhibits CD45 (IC50 = 200 nM).

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Storage

2-8C

Featured in Publications

1) Cojohari, O., et al. (2016). Human cytomegalovirus induces an atypical activation of Akt to stimulate the survival of short-lived monocytes. J Virol 90(14): 6443-6452. 2) Yousefi, B., et al. (2017). Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARgamma-dependent manner in leukemia cells. Tumor Biology 39(10): 1010428317716501. 3) Alsina-Sanchis, E., et al. (2018). ALK1 (Activin-Receptor Like Kinase 1) Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K (Phosphatidylinositol 3-Kinase) Activation. Arteriosclerosis, thrombosis, and vascular biology 38(5): 1216-1229. 4) Mitchell, J., et al. (2018). Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice. Inflammatory Bowel Diseases 24(8): 1718-1732.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Inhibitor, PI3K, PTEN. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature