PF-8380 (Autotaxin Inhibitor)

Product Overview

• Article Name: PF-8380 (Autotaxin Inhibitor)
• Biozol Catalog Number: ECH-B-0702
• Supplier Catalog Number: B-0702
• Alternative Catalog Number: ECH-B-0702-10MG,ECH-B-0702-1MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

PF-8380 is a potent autotaxin (ATX) inhibitor (IC50 2.8 nM/101 nM purified enzyme/whole blood). Excessive activity of ATX is associated with numerous inflammatory conditions, cancers and other disease. Lysophosphatidic acid (LPA) produced by ATX stimulates cell proliferation through G-protein coupled receptorsLPA1-4. PF-8380 is orally bioavailable and effectively inhibits ATX in vivo reducing LPA levels in serum and at the site of inflammation in a rat arthritis model. Can delivered orally with the Oral Formulation Vehicle.

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Storage

2-8 C

References

Gierse, J. et al (2010) A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation> Journal of Pharmacology and Experimental Therapeutics 334(1):310.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Biochemical Reagents. Related: Autotaxin, Inhibitor. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature