7-azido-4-methylcoumarin (AzMC Hydrogen sulfide detector), CAS [[95633-27-5]]

Product Overview

• Article Name: 7-azido-4-methylcoumarin (AzMC Hydrogen sulfide detector), CAS [[95633-27-5]]
• Biozol Catalog Number: ECH-D-0010-1MG
• Supplier Catalog Number: D-0010-1mg
• Alternative Catalog Number: ECH-D-0010-1MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

This novel and selective probe for hydrogen sulfide (H2S) 7-azido-4-methylcoumarin (AzMC) is useful for monitoring cystathionine B-synthase (CBS) catalyzed reactions which play a critical role in human sulfur metabolism. Deactivated CBS is characterized by high plasma levels of homocysteine and H2S resulting in clinical manifestations of numerous disease states. AzMC used as a fluorgenic probe and concurrent CBS activity can be used to select compounds for activation or inhibition of this enzyme and is suitable for high-throughput screening and the development of potential therapeutics. In addition AzMC has been used as a photoaffinitry probe for the substrate binding site of human phenol sulfotransferase (SULT1A-1 or P-PST-1).Featured in References1. M.K. Thorson T. Majtan J.P. Kraus A.M. Barrios Identification of Cystathionine i-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe. Angewandte Chemie (Int. ed. Eng.) 2013 52 4641-4144. DOI: 10.1002/anie.2013008412. G. Chen et al. Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase (SULT1A1): 7-azido-4-methylcoumarin. Protein Sci. 1999 8 2151-2157 doi:10.1110/ps.8.10.21513. Q-L Xie et a. An azidocoumarin-based fluorescent probe for imaging lysosomal hydrogen sulfide in living cells Analytical Methods 2017 DOI: 10.1039/C7AY00862G Bulk discounts available please email echelon echelon-inc.com for information.

Product Properties

• Tag: 313 314 315
• CAS Number: [95633-27-5]