XY-4 (LPA analog)

Product Overview

• Article Name: XY-4 (LPA analog)
• Biozol Catalog Number: ECH-L-1160
• Supplier Catalog Number: L-1160
• Alternative Catalog Number: ECH-L-1160-500UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

(2R)-1,1-difluoro-2-palmitoyloxy-3-phosphopropane (XY-4) is an analog of 2-palmitoyl lysophosphatidic acid (LPA) in which the sn-1 hydroxyl has been replaced by two fluorines. It acts as a selective agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) but does not stimulate LPA1, LPA2, or LPA3 receptors. PPARgamma is a transcription factor of the nuclear receptor superfamily and has been implicated in atherogenesis.

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Storage

-20 C

Featured in Publications

1) Zhang, C., D. L. Baker, et al. (2004). Lysophosphatidic Acid Induces Neointima Formation Through PPARgamma Activation. The Journal of Experimental Medicine 199(6): 763-774. 2) McIntyre, T. M., A. V. Pontsler, et al. (2003). Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proceedings of the National Academy of Sciences 100(1): 131-136.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Lipids. Related: Lysophospholipid. Ship 1 : Shipping Temp. Ship 2: Gel Ice