PEG derivatized lipids are used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. The hydrophilic PEG chains decrease interactions with the reticular-endothelial system and increases the size of the particles both of which result in lowered clearance rate from the body. The biotin group allows the lipid to be bound to streptavidin conjugated biomolecules or surfaces.
Application Notes:
Categories: Lipids
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