Thio-ccPA

Product Overview

• Article Name: Thio-ccPA
• Biozol Catalog Number: ECH-L-7118
• Supplier Catalog Number: L-7118
• Alternative Catalog Number: ECH-L-7118-1MG, ECH-L-7118-500UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). It inhibits the lysoPLD activity of Autotaxin (ATX) and acts as an LPA1/3 receptor antagonist. Thio-ccPA decreases the viability of B16F10, A375, and MeWo melanoma cell lines. Addition of endogenous LPA did not reverse these effects in B16F10 cells. Thio-ccPA decreased the number of pulmonary and non-pulmonary metastases in a B16F10 metastatic melanoma mouse model.

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Storage

-20 C

Featured in Publications

1) Xu, Y., G. Jiang, et al. (2006). Phosphonothioate and Fluoromethylene Phosphonate Analogues of Cyclic Phosphatidic Acid: Novel Antagonists of Lysophosphatidic Acid Receptors. Journal of Medicinal Chemistry 49(17): 5309. 2) Altman, M. K., V. Gopal, et al. (2010). Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol Cancer 9: 140.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Lipids. Related: Lysophospholipid. Ship 1 : Shipping Temp. Ship 2: Gel Ice