Oleoyl 3-carbacyclic Phosphatidic Acid, CAS [[779333-58-3]]
Biozol Catalog Number:
ECH-L-7218-500UG
Supplier Catalog Number:
L-7218-500ug
Alternative Catalog Number:
ECH-L-7218-500UG
Manufacturer:
Echelon Biosciences
Category:
Molekularbiologie
Oleoyl 3-carbacyclic Phosphatidic Acid (ccPA) is an analog of naturally occurring cyclic phosphatidic acid in which the sn-3 oxygen has been replaced with carbon making a stable phosphonate with is resistant to ring opening. ccPA is an analog of LPA but does not activate the LPA1-4 receptors. It also acts as a potent inhibitor of Autotaxin and can inhibit the metastasis of B16-F10 melanoma cells when injected into mice.References1) Baker D. L. et al. Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasisa€ J. Biol. Chem. 2006 281 22786.2) Uchiyama A. et al. a€Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid.a€ Biochim. Biophys. Acta 2007 1771 103.3) Williams J. R. et al a€Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activationa€ J. Biol. Chem. 2009 284 17304.
Tag:
745 746 743 443
CAS Number:
[779333-58-3]
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