ATX100 is a biodegradable ionizable lipid with improved in vivo activities for siRNA delivery via lipid nanoparticles (LNP). The physicochemical parameters of ATX100: pKa 6.316, lipophilicity cLogD 14.03, nanoparticle size 82 nm. The in vivo factor VII knockdown efficiency of ATX100 is 97% (0.03mg/kg in mice, i.v.).
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