PI(3,4)P2 diC8

Product Overview

• Article Name: PI(3,4)P2 diC8
• Biozol Catalog Number: ECH-P-3408
• Supplier Catalog Number: P-3408
• Alternative Catalog Number: ECH-P-3408-100UG,ECH-P-3408-1MG,ECH-P-3408-500UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4)P2. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

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Featured in Publication

1. Elge, S., C. Brearley, et al. (2001). An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors. Plant J 26(6): 561-71. 2. Tong, Q., N. Gamper, et al. (2004). Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J Biol Chem 279(21): 22654-63. 3. Shen, J., et al. (2009). Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol 11(6): 769-776. 4. Lopez, S. M., et al. (2013). Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. Biochem Biophys Res Commun 440(2): 277-282. 5. Choi, S., et al. (2019). A nuclear phosphoinositide kinase complex regulates p53. Nature cell biology 21: 462-475. Product Keywords: Dioctanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 C8, PI(3,4)P2 C8, or PI34P2. Bulk discounts available, please email echelon echelon-inc.com for details.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Lipids. Related: diC8, PI(3\,4)P3. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination