PI(3,4,5)P3 diC4 (Phosphatidylinositol 3,4,5-trisphosphate diC4) is a synthetic, purified dibutanoyl PI(3,4,5)P3. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Featured in Publications 1. Thapar, R., A. E. Karnoub, et al. (2002). Structural and biophysical insights into the role of the insert region in Rac1 function. Biochemistry 41(12): 3875-83. 2. He, J., R. M. Haney, et al. (2008). Molecular mechanism of membrane targeting by the GRP1 PH domainboxs. J Lipid Res 49(8): 1807-15. 3. Lumb, C. N., J. He, et al. (2011). Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain. Structure 19(9): 1338-46. 4. Agamasu, C., et al. (2016). The Interplay Between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt. The Journal of Biological Chemistry 292: 251-263. 5. Zhao, W., et al. (2019). Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res 29: 895-910. Product Keywords: Dibutanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (4:0/4:0), PI(3,4,5)P3 (4:0/4:0), or PIP3 Bulk discounts available, please email echelon echelon-inc.com for information.
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