PI(3,4,5)P3 diC8 (Phosphatidylinositol 3,4,5-trisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4,5)P3. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Featured in Publications 1. Paternotte, N., J. Zhang, et al. (2005). SHIP2 interaction with the cytoskeletal protein Vinexin. FEBS J 272(23): 6052-66. 2. Odriozola, L., G. Singh, et al. (2007). Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem 282(32): 23306-15. 3. Hubbard, L. L., C. A. Wilke, et al. (2011). PTEN Limits Alveolar Macrophage Function Against Pseudomonas aeruginosa Following Bone Marrow Transplantation. Am J Respir Cell Mol Biol 45(5): 1050-1058. 4. Steidle, E. A., et al. (2016). A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae: Siw14 selectively cleaves the i-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5). J. Biol. Chem. 291: 6772-6783. 5. Somasundaram, R., et al. (2017). Analysis of SHIP1 expression and activity in Crohna€(TM)s disease patients. PLoS ONE 12(8): e0182308. 6. Patel, V. B., et al. (2018). PI3Kalpha-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease. Nature Communications 9(1): 5390. Product Keywords: Dioctanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (8:0/8:0), PI(3,4,5)P3 C8, or PIP3 Bulk discounts available, please email echelon echelon-inc.com for information.
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