Glycerophosphoinositol 4,5-diphosphate (GroPI(4,5)P2) is a synthetic, purified PI(4,5)P2 without acyl chains at the 1- and 2-positions of the glycerol. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).
