PI4-Kinase beta (PI4Kb), active
Catalog Number:
ECH-P32-102G
| Article Name: |
PI4-Kinase beta (PI4Kb), active |
| Biozol Catalog Number: |
ECH-P32-102G |
| Supplier Catalog Number: |
P32-102G |
| Alternative Catalog Number: |
ECH-P32-102G-10UG,ECH-P32-102G-5UG |
| Manufacturer: |
Echelon Biosciences |
| Category: |
Molekularbiologie |
PI4-Kinase beta (PI4Kb), active is a full-length, recombinant human PI4KB co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem. Molecular weight: ~120 kDa Sequence: Full length Species: Human Tag: GST tag Purity: >90 % (request TDS for lot specific information) Specific Activity: >30 nmol/min/mg (request TDS for lot specific information) Expression System: Sf9 insect cells using baculovirus Genebank Number: BC000029 Applications: PI 4-Kinase assay , western blot. Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. Storage and stability: Store product at -70C. Stable up to one year.
Product Background PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol. PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor.
|
| Application Notes: |
Categories: Antibodies & Proteins. Related: Enzyme, Kinase, PI4K. Ship 1 : Shipping Temp. Ship 2: Dry Ice |
