Sphingosine is formed through ceramidase catalyzed hydrolysis of ceramide. It is a potent inhibitor of protein kinase C (IC50 = 1-3 µM). Sphingosine is phosphorylated by sphingosine kinase to the bioactive lipid sphingosine 1-phosphate. Sphingosine-Cyanine5 is labeled with the red-shifted Cy5 dye for measurement and imaging with 647 nm excitation. Technical Data Sheet
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Categories: Lipids
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