Biotinylated Anti-PtdIns(4,5)P2 IgM

Product Overview

• Article Name: Biotinylated Anti-PtdIns(4,5)P2 IgM
• Biozol Catalog Number: ECH-Z-B045
• Supplier Catalog Number: Z-B045
• Alternative Catalog Number: ECH-Z-B045-10UG,ECH-Z-B045-250UG,ECH-Z-B045-50UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Purified Anti-PtdIns(4,5)P2 monoclonal antibody conjugated with biotin. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip), Flow Cytometry

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Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.

Storage

2-8 C for up to 30 days, -20 C for greater than 30 days. Do not freeze thaw multiple times

Featured in Publications

1) Hoek, K. L., P. Antony, et al. (2006). Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J Immunol 177(8): 5405-13. 2) Antony, P., K. Hoek, et al. (2007). Micro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations. Biol Proced Online 9: 73-83. 3) Marquez, M. G., C. Fernandez-Tome Mdel, et al. (2009). Bradykinin induces formation of vesicle-like structures containing vinculin and PtdIns(4,5)P2 in renal papillary collecting duct cells. Am J Physiol Renal Physiol 297(5): F1181-91. Product keywords: PIP2, PI(4,5)P2, PtdIns(4,5)P2, IgM, anti-PIP2

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Antibodies & Proteins. Related: Antibody, Biotinylated, Lipid Binding, PI(4\,5)P2. Ship 1 : Shipping Temp. Ship 2: Dry Ice