Fluorescein conjugated Anti-PI(3,4,5)P3 IgM

Product Overview

• Article Name: Fluorescein conjugated Anti-PI(3,4,5)P3 IgM
• Biozol Catalog Number: ECH-Z-G345
• Supplier Catalog Number: Z-G345
• Alternative Catalog Number: ECH-Z-G345-10UG,ECH-Z-G345-250UG,ECH-Z-G345-50UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with fluorescein. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence

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Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

Protect from light. 2-8 C for up to 30 days, -20 C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Vedham, V., H. Phee, et al. (2005). Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol 25(10): 4211-20. 2) Gupta, S., A. R. Ramjaun, et al. (2007). Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129(5): 957-68. 3) Lin, H. V., L. Plum, et al. (2010). Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons. Diabetes 59(2): 337-346. Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Antibodies & Proteins. Related: Antibody, Fluorescent, Lipid Binding, PI(3\,4\,5)P3. Ship 1 : Shipping Temp. Ship 2: Dry Ice