Anti-PtdIns(3,4,5)P3 IgM HRP

Product Overview

• Article Name: Anti-PtdIns(3,4,5)P3 IgM HRP
• Biozol Catalog Number: ECH-Z-H345
• Supplier Catalog Number: Z-H345
• Alternative Catalog Number: ECH-Z-H345-10UG, ECH-Z-H345-250UG, ECH-Z-H345-50UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with horseradish peroxidase. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence

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Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 C for up to 30 days, -20 C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Garcia-San Frutos, M., T. Fernandez-Agullo, et al. (2007). Impaired central insulin response in aged Wistar rats: role of adiposity. Endocrinology 148(11): 5238-47. Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Antibodies & Proteins. Related: Antibody, Lipid Binding, PI(3\,4\,5)P3