Sphingosine 1-Phosphate Antibody

Product Overview

• Article Name: Sphingosine 1-Phosphate Antibody
• Biozol Catalog Number: ECH-Z-P300
• Supplier Catalog Number: Z-P300
• Alternative Catalog Number: ECH-Z-P300-10UG,ECH-Z-P300-250UG,ECH-Z-P300-50UG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Purified Anti-Sphingosine 1-Phosphate (S1P) monoclonal antibody. Subclass: IgGk1 Source: Mouse Applications: ELISA, Immunohistochemistry, Immunocytochemistry

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Product Background: Sphingosine 1-Phosphate (S1P) is a key component of the sphingolipid signaling cascade. S1P initiates a proliferative, pro-angiogenic and anti-apoptotic sequence of events contributing to cancer progression. Recently, scientific literature has suggested that S1P is a potent tumorigenic growth factor that is likely released from tumor cells and that S1P may be a novel biomarker for early stage cancer detection. Sphingosine kinase has also been shown to be up-regulated in a variety of cancer types. S1P antibody (LT1002) was originally developed and patented at Lpath Therapeutics.

Storage

Antibody is stable for up to 1 year at -20 C. Antibody is stable for 60 days at 4C. Avoid repeated freeze/thaw cycles.

References

1) Visentin B, Reynolds G, Sabbadini R. (2012) Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples. Methods Mol Biol. 874:55-67. 2) OBrien N, Jones ST, Williams DG, Cunningham HB, Moreno K, Visentin B, et al. (2009) Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res.,50(11):2245-57. 3) Swaney JS, Moreno KM, Gentile AM, Sabbadini RA, Stoller GL. (2008) Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res.,87(4):367-75. Bulk discounts available, please email echelon echelon-inc.com for information.

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Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Antibodies & Proteins. Related: Antibody, Lipid Binding, Sphingosine 1-phosphate. Ship 1 : Shipping Temp. Ship 2: Dry Ice