MSH2 Mouse Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: MSH2 Mouse Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMM80515
• Supplier Catalog Number: AMM80515
• Alternative Catalog Number: EKL-AMM80515-50UL,EKL-AMM80515-100UL
• Manufacturer: EnkiLife
• Host: Mouse
• Category: Antikörper
• Application: ELISA, ICC, IHC, WB
• Species Reactivity: Human, Mouse
• Conjugation: Unconjugated
• Alternative Names: FCC1, COCA1, HNPCC, LCFS2

Product Description

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA
replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic
colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal
(HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic
information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI).
These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 105kDa
• NCBI: 4436
• UniProt: P43246
• Buffer: Purified antibody in PBS with 0.05% sodium azide.
• Purity: Affinity Purification
• Form: Liquid
• Target: MSH2

Application Notes

• Application Dilute: WB 1:500-1:2000,IHC 1:100-1:500,ICC 1:50-1:500,ELISA 1:5000-1:20000