HLA B7 (14R14) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: HLA B7 (14R14) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE12077
• Supplier Catalog Number: AMRe12077
• Alternative Catalog Number: EKL-AMRE12077-50UL, EKL-AMRE12077-100UL, EKL-AMRE12077-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, WB
• Species Reactivity: Human
• Conjugation: Unconjugated
• Alternative Names: HLA B, HLAB,

Product Description

HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 40kDa
• NCBI: 3106
• UniProt: P01889
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: HLA-B

Application Notes

• Application Dilute: WB 1:1000-1:5000,IHC 1:200-1:500,IF-P 1:200-1:500