PRPF8 (19L6) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: PRPF8 (19L6) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE16552
• Supplier Catalog Number: AMRe16552
• Alternative Catalog Number: EKL-AMRE16552-50UL, EKL-AMRE16552-100UL, EKL-AMRE16552-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: Unconjugated
• Alternative Names: HPRP8, p220, PRP8, PRPC8, Prpf8, RP13, SNRNP220,

Product Description

Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5- and 3-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5-splice sites in B spliceosomes and 3-splice sites in C spliceosomes. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5 and the 3 splice site.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 274kDa
• NCBI: 10594
• UniProt: Q6P2Q9
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: PRPF8

Application Notes

• Application Dilute: WB 1:1000-1:5000,IHC 1:50-1:100,IF-P 1:50-1:100