VAMP8 (8R11) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE19708
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| Article Name: | VAMP8 (8R11) Rabbit Monoclonal Antibody, Unconjugated |
| Biozol Catalog Number: | EKL-AMRE19708 |
| Supplier Catalog Number: | AMRe19708 |
| Alternative Catalog Number: | EKL-AMRE19708-50UL, EKL-AMRE19708-100UL, EKL-AMRE19708-200UL |
| Manufacturer: | EnkiLife |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | FC, ICC, IHC, IP, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Conjugation: | Unconjugated |
| Alternative Names: | VAMP8, EDB, Endobrevin, VAMP-8, |
| Proteins in the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex are integral membrane proteins involved in vesicle transport and membrane fusion by pairing of vesicular SNAREs (v-SNAREs) with cognate target SNAREs (t-SNAREs). Vesicle associated membrane protein 8 (VAMP8), also known as endobrevin, is a v-SNARE originally found preferentially localized to early endosomes. SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946). |
| Clonality: | Monoclonal |
| Molecular Weight: | 11kDa |
| NCBI: | 8673 |
| UniProt: | Q9BV40 |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Purity: | Affinity purification |
| Form: | Liquid |
| Target: | VAMP8 |
| Application Dilute: | WB 1:2000-1:20000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:50-1:100,IP 1:20-1:50 |
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