WASP (3Z3) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: WASP (3Z3) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE19862
• Supplier Catalog Number: AMRe19862
• Alternative Catalog Number: EKL-AMRE19862-50UL, EKL-AMRE19862-100UL, EKL-AMRE19862-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: FC, ICC, WB
• Species Reactivity: Human
• Conjugation: Unconjugated
• Alternative Names: IMD2, SCNX, THC, THC1, U42471, Was, WASp,

Product Description

Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 53kDa
• NCBI: 7454
• UniProt: P42768
• Buffer: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
• Purity: Affinity purification
• Form: Liquid
• Target: WAS

Application Notes

• Application Dilute: WB 1:2000-1:20000,ICC/IF 1:20-1:50,FC 1:20-1:50