Wilms Tumor Protein (13C17) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: Wilms Tumor Protein (13C17) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE19901
• Supplier Catalog Number: AMRe19901
• Alternative Catalog Number: EKL-AMRE19901-50UL, EKL-AMRE19901-100UL, EKL-AMRE19901-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: FC, ICC, IHC, WB
• Species Reactivity: Human, Mouse
• Conjugation: Unconjugated
• Alternative Names: GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1,

Product Description

Has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3 (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 49kDa
• NCBI: 7490
• UniProt: P19544
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: WT1

Application Notes

• Application Dilute: WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50,FC 1:20-1:50