Cell localization:Cytoplasmic, Nuclear.nuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regµLates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. MµLtiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],