CASP5, Apoptosis related cysteine protease, CASP-5, Caspase-5 subunit p10, Protease ICH-3, TY protease,,Caspase 5
Thiol protease that acts as a mediator of programmed cell death.Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis.