ECPTP, NC PTPCOM1, PTPBR7, PTPRQ, PTPRR, PTPSL, Receptor type tyrosine protein phosphatase R,,PTPRR
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).