AD3, Ad3h, FAD, Protein S182, PS1-CTF12, PSEN1, PSNL1, S182,,Presenilin 1
Requires the presence of the other members of the gamma-secretase complex for protease activity.Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.