TP53BP1, Tumor suppressor p53-binding protein 1, 53BP1, p53-binding protein 1, p53BP1
function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at Lys-20 is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on Ser-139. Interacts with histone H4 that has been dimethylated at Lys-20. Has low affinity for histone H4 containing monomethylated Lys-20. Does not bind histone H4 containing unmethylated or trimethylated Lys-20. Has low affinity for histone H3 that has been dimethylated on Lys-79. Has very low affinity for histone H3 that has been monomethylated on Lys-79 (in vitro). Does not bind unmethylated histone H3.,function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at Lys-20 is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on Ser-139. Interacts with histone H4 that has been dimethylated at Lys-20. Has low affinity for histone H4 containing monomethylated Lys-20. Does not bind histone H4 containing unmethylated or trimethylated Lys-20. Has low affinity for histone H3 that has been dimethylated on Lys-79. Has very low affinity for histone H3 that has been monomethylated on Lys-79 (in vitro). Does not bind unmethylated histone H3.,
