AKAP14, AKAP28, A-kinase anchor protein 14, AKAP-14, A-kinase anchor protein 28 kDa, AKAP 28, Protein kinase A-anchoring protein 14, PRKA14
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Binds to type II regulatory subunits of protein kinase A and anchors/targets them.,subunit:Binds to type II regulatory subunits (RII).,tissue specificity:Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.,
