APOL3, Apolipoprotein L3, Apolipoprotein L-III, ApoL-III, TNF-inducible protein CG12-1, CG12_1
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015],function:May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.,induction:In vitro, is responsive to tumor necrosis factor.,similarity:Belongs to the apolipoprotein L family.,tissue specificity:Widely expressed, the highest levels are in prostate, lung and placenta, also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland, levels are low in brain, heart, fetal liver, pancreas and testis.,
