APPBP2, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],function:May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.,PTM:Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.,similarity:Contains 8 TPR repeats.,subcellular location:Associated with membranes and microtubules.,subunit:Binds APP.,
