This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5 UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],domain:N-terminus mediates homodimerization.,domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.,function:One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.,PTM:The N-terminus is blocked.,similarity:Contains 6 WD repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.,
