myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer, disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,
