CDK5RAP3, IC53, MSTP016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit-associated protein 3, CDK5 activator-binding protein C53, Protein HSF-27
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013],function:Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1.,PTM:Phosphorylated in vitro by CDK5.,similarity:Belongs to the CDK5RAP3 family.,subunit:Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein.,tissue specificity:Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.,
