The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008],alternative products:Additional isoforms seem to exist,function:Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.,function:Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.,PTM:Highly O-glycosylated and probably also N-glycosylated.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 SEA domain.,tissue specificity:Broad specificity, small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.,tissue specificity:Fetal and adult small intestine and fetal and adult colon.,
