Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008],catalytic activity:A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Magnesium.,enzyme regulation:Activated by ADP.,function:Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.,similarity:Belongs to the 5-nucleotidase type 3 family.,tissue specificity:Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.,
