TERF2IP, DRIP5, RAP1, PP8000, Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homol
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2, seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TRF2 (but not TRF1) with its C-terminus.,tissue specificity:Ubiquitous. Highly expressed.,
