RNF130, E3 ubiquitin-protein ligase RNF130, Goliath homolog, H-Goliath, RING finger protein 130
ring finger protein 130(RNF130) Homo sapiens The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],function:May have a role during the programmed cell death of hematopoietic cells.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,
