septin 8(SEPT8) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],similarity:Belongs to the septin family.,subunit:Interacts with SEPT5.,tissue specificity:Expressed in brain, heart and platelets, most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen, whereas isoforms 1 and 3 are highly expressed in these areas. In prostate, testis and ovary, isoform 2 is highly expressed, while isoforms 1 and 3 found at low levels.,
