TBC1D3, PRC17, TBC1D3A, TBC1 domain family member 3, Prostate cancer gene 17 protein, Protein TRE17-alpha, Rab GTPase-activating protein PRC17, TBC1D3B, TBC1D3I, TBC1 domain family member 3B, TBC1D3C, TBC1D3D, TBC1 domain family member 3C
This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,
