Transforming growth factor beta-3, TGFB3, TGF-beta-3, Latency-associated peptide, LAP
Transforming growth factor beta 3(TGFB3) is a member of a TGF -beta superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- beta RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-beta3,mammals develop a deformity known as a cleft palate.
