Defensins are cationic peptides. It is an important ingredient of the innate immune system. beta-defensins are expressed on some leukocytes and epithelial surfaces. Four human beta-Defensins have been identified to date: BD-1, BD-2, BD-3 and BD-4. beta-defensins contain a six-cysteine motif, they forms three intra-molecular disulfide bonds. beta-defensins are also chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, they are released by proteolytic cleavage of a signal sequence.
Greater than 95% as determined by reducing SDS-PAGE
Application Notes:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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