Aminoglycoside 3-phosphotransferase, APH(3)-II, APH(3)II, Kanamycin kinase type II, Neomycin-kanamycin phosphotransferase type II, neo
Aminoglycoside 3-phosphotransferase (APH(3)), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity, hence resistance is conferred to the drugs that are phosphorylated. APH(3) is primarily found in certain species of gram-positive bacteria.
